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Mark R Cookson Selected Research

Leucine (L-Leucine)

11/2022LRRK2 recruitment, activity, and function in organelles.
1/2022Directing LRRK2 to membranes of the endolysosomal pathway triggers RAB phosphorylation and JIP4 recruitment.
1/2022Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk.
1/2022Evaluation of Current Methods to Detect Cellular Leucine-Rich Repeat Kinase 2 (LRRK2) Kinase Activity.
12/2021Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
1/2021Preclinical modeling of chronic inhibition of the Parkinson's disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo.
1/2021Generation of fourteen isogenic cell lines for Parkinson's disease-associated leucine-rich repeat kinase (LRRK2).
1/2020In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson's Disease in Common Marmosets.
1/2020Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis.
1/2020The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network.
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Mark R Cookson Research Topics

Disease

101Parkinson Disease (Parkinson's Disease)
11/2022 - 03/2002
22Parkinsonian Disorders (Parkinsonism)
01/2019 - 11/2003
9Alzheimer Disease (Alzheimer's Disease)
01/2021 - 10/2007
8Neurodegenerative Diseases (Neurodegenerative Disease)
01/2021 - 02/2004
7Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
01/2017 - 06/2002
5Mitochondrial Diseases (Mitochondrial Disease)
01/2022 - 05/2006
5Dystonia (Limb Dystonia)
10/2017 - 08/2004
5Neuroblastoma
10/2014 - 08/2002
4Dementia (Dementias)
10/2020 - 08/2004
4Neoplasms (Cancer)
12/2018 - 01/2012
3Inflammation (Inflammations)
01/2021 - 01/2012
3Lewy Body Disease (Lewy Body Dementia)
01/2020 - 02/2005
3Gaucher Disease (Gaucher's Disease)
06/2013 - 07/2011
2Disease Progression
01/2021 - 01/2019
2Synucleinopathies
10/2020 - 09/2011
2Multiple System Atrophy
10/2020 - 08/2004
2Nervous System Diseases (Neurological Disorders)
01/2019 - 07/2013
2Crohn Disease (Crohn's Disease)
12/2018 - 10/2016
2Leprosy (Hansen's Disease)
12/2018 - 10/2016
2Frontotemporal Dementia (Semantic Dementia)
01/2017 - 05/2014
2Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)
09/2012 - 02/2004
1Muscular Dystrophies (Muscular Dystrophy)
11/2021
1Cognitive Dysfunction
10/2021
1Genetic Risk Score
01/2021
1Gliosis
01/2021
1Infections
10/2017
1Ataxia (Dyssynergia)
01/2017
1Tremor (Tremors)
01/2017
1Movement Disorders (Movement Disorder)
01/2014
1Tauopathies
07/2013
1Corticobasal Degeneration
09/2012
1Late Onset Disorders
01/2012
1Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar)
12/2010
1Dystonia 16
03/2008
1Juvenile Amyotrophic Lateral Sclerosis 2
11/2006

Drug/Important Bio-Agent (IBA)

57Phosphotransferases (Kinase)IBA
11/2022 - 12/2005
47Proteins (Proteins, Gene)FDA Link
11/2022 - 12/2002
46Leucine (L-Leucine)FDA Link
11/2022 - 06/2007
14alpha-SynucleinIBA
03/2010 - 03/2002
11SynucleinsIBA
01/2021 - 12/2010
8GTP Phosphohydrolases (GTPases)IBA
12/2019 - 02/2008
5Dopamine (Intropin)FDA LinkGeneric
01/2021 - 05/2003
5PTEN-induced putative kinaseIBA
09/2014 - 04/2005
4EnzymesIBA
01/2021 - 01/2010
4Biological ProductsIBA
01/2021 - 10/2003
4Apolipoproteins E (ApoE)IBA
01/2020 - 03/2013
4RNA (Ribonucleic Acid)IBA
05/2014 - 07/2008
4UbiquitinIBA
05/2006 - 08/2002
4Proteasome Endopeptidase Complex (Proteasome)IBA
05/2006 - 12/2002
3Glucosylceramidase (Glucocerebrosidase)IBA
01/2020 - 07/2011
3Protein Isoforms (Isoforms)IBA
01/2014 - 02/2004
3Messenger RNA (mRNA)IBA
09/2012 - 12/2007
3Superoxide Dismutase-1IBA
09/2002 - 06/2002
2IronIBA
05/2022 - 12/2021
2Transferrin (beta 2 Transferrin)IBA
05/2022 - 12/2021
2Leucine-Rich Repeat Serine-Threonine Protein Kinase-2IBA
01/2022 - 02/2016
2Protein Kinases (Protein Kinase)IBA
01/2021 - 01/2021
2ProgranulinsIBA
01/2021 - 12/2010
2ClathrinIBA
01/2020 - 01/2019
2ApolipoproteinsIBA
01/2020 - 01/2017
2Heat-Shock Proteins (Heat-Shock Protein)IBA
01/2019 - 05/2003
2RNA-Binding Proteins (RNA-Binding Protein)IBA
01/2017 - 01/2012
2Cysteine (L-Cysteine)FDA Link
09/2014 - 03/2009
2Pharmaceutical PreparationsIBA
09/2011 - 01/2008
2Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
09/2009 - 07/2003
2cysteine sulfinic acidIBA
03/2009 - 06/2004
2RotenoneIBA
05/2006 - 08/2002
1CollagenIBA
11/2021
1Memantine (Namenda)FDA Link
10/2021
1Glycoproteins (Glycoprotein)IBA
01/2021
1ClusterinIBA
01/2021
1Protein AggregatesIBA
01/2020
1NucleotidesIBA
12/2019
1rab GTP-Binding ProteinsIBA
01/2019
1AuxilinsIBA
01/2019
1Biomarkers (Surrogate Marker)IBA
01/2018
1InflammasomesIBA
10/2017
1Transcription Factors (Transcription Factor)IBA
10/2017
1p21-Activated KinasesIBA
12/2015
1Dexfenfluramine (Redux)IBA
10/2015
1DNA-Binding Proteins (DNA Binding Protein)IBA
05/2014
1TubulinIBA
01/2014
1Leucine-Rich Repeat ProteinsIBA
01/2014
1MicroRNAs (MicroRNA)IBA
09/2013
1Brain-Derived Neurotrophic Factor (BDNF)IBA
07/2013
1Antidepressive Agents (Antidepressants)IBA
07/2013
1Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
09/2012
1Carrier Proteins (Binding Protein)IBA
01/2012
1MicellesIBA
10/2011
1Lipid Bilayers (Lipid Bilayer)IBA
10/2011
1Ubiquitin CIBA
03/2009
1CeramidesIBA
12/2008
1Levodopa (L Dopa)FDA LinkGeneric
03/2008
1Tissue Inhibitor of Metalloproteinase-3IBA
10/2007
1CalciumIBA
11/2006
1alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA
11/2006
1AMPA Receptors (AMPA Receptor)IBA
11/2006
1Glutamate Receptors (Glutamate Receptor)IBA
11/2006

Therapy/Procedure

3Therapeutics
12/2018 - 03/2008
1Drug Therapy (Chemotherapy)
07/2013